Kalp Hastal\u0131\u011f\u0131nda Yeni Bir Risk Fakt\u00f6r\u00fc G\u00fcndemde
Kalp hastal\u0131klar\u0131 denince \u00e7o\u011fu ki\u015finin akl\u0131na \u201ckolesterol\u201d gelir. Uzun y\u0131llard\u0131r da en \u00e7ok LDL kolesterol (k\u00f6t\u00fc kolesterol) \u00fczerine odaklan\u0131l\u0131r.
Ancak son y\u0131llarda bilim d\u00fcnyas\u0131 \u00f6nemli bir \u015feyi daha fark etti:
Kolesterol normal olsa bile baz\u0131 ki\u015filerde kalp krizi riski devam edebiliyor.
\u0130\u015fte bu noktada yeni bir kavram \u00f6ne \u00e7\u0131k\u0131yor: Lipoprotein(a)<\/p>\n\n\n\n
Lipoprotein(a) Nedir?<\/strong> Neden \u00d6nemli? Kolesterol \u0130la\u00e7lar\u0131 Lp(a)\u2019y\u0131 Etkiler mi? Yeni Umut: Genetik D\u00fczeyde Tedaviler Bu Ne Anlama Geliyor? Kimler Lp(a) \u00d6l\u00e7t\u00fcrmeli? Sonu\u00e7 Kalp Hastal\u0131\u011f\u0131nda Yeni Bir Risk Fakt\u00f6r\u00fc G\u00fcndemdeKalp hastal\u0131klar\u0131 denince \u00e7o\u011fu ki\u015finin akl\u0131na \u201ckolesterol\u201d gelir. Uzun y\u0131llard\u0131r da en \u00e7ok LDL kolesterol (k\u00f6t\u00fc kolesterol) \u00fczerine odaklan\u0131l\u0131r.Ancak son y\u0131llarda bilim d\u00fcnyas\u0131 \u00f6nemli bir \u015feyi daha fark etti:Kolesterol normal olsa bile baz\u0131 ki\u015filerde kalp krizi riski devam edebiliyor.\u0130\u015fte bu noktada yeni bir kavram \u00f6ne \u00e7\u0131k\u0131yor: Lipoprotein(a) Lipoprotein(a) Nedir?Lipoprotein(a), […]<\/p>\n","protected":false},"author":2,"featured_media":8128,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8127","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dental-services"],"_links":{"self":[{"href":"https:\/\/alibuturak.com\/en\/wp-json\/wp\/v2\/posts\/8127","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alibuturak.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/alibuturak.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/alibuturak.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/alibuturak.com\/en\/wp-json\/wp\/v2\/comments?post=8127"}],"version-history":[{"count":1,"href":"https:\/\/alibuturak.com\/en\/wp-json\/wp\/v2\/posts\/8127\/revisions"}],"predecessor-version":[{"id":8129,"href":"https:\/\/alibuturak.com\/en\/wp-json\/wp\/v2\/posts\/8127\/revisions\/8129"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/alibuturak.com\/en\/wp-json\/wp\/v2\/media\/8128"}],"wp:attachment":[{"href":"https:\/\/alibuturak.com\/en\/wp-json\/wp\/v2\/media?parent=8127"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/alibuturak.com\/en\/wp-json\/wp\/v2\/categories?post=8127"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/alibuturak.com\/en\/wp-json\/wp\/v2\/tags?post=8127"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Lipoprotein(a), kanda bulunan ve LDL kolesterole benzeyen bir ya\u011f-protein par\u00e7ac\u0131\u011f\u0131d\u0131r.
Ama \u00f6nemli farklar\u0131 vard\u0131r:
\u2022 B\u00fcy\u00fck \u00f6l\u00e7\u00fcde genetik olarak belirlenir
\u2022 Diyet ve egzersizden \u00e7ok az etkilenir
\u2022 Damar sertli\u011fini art\u0131rabilir
\u2022 Ayn\u0131 zamanda p\u0131ht\u0131la\u015fma e\u011filimini y\u00fckseltebilir
Yani sadece \u201ckolesterol\u201d de\u011fil, ayn\u0131 zamanda damar t\u0131kan\u0131kl\u0131\u011f\u0131n\u0131 kolayla\u015ft\u0131ran \u00f6zel bir risk fakt\u00f6r\u00fcd\u00fcr.<\/p>\n\n\n\n
<\/strong>Ara\u015ft\u0131rmalar g\u00f6steriyor ki:
\u2022 Lipoprotein(a) y\u00fcksek olan ki\u015filerde
\u2022 kalp krizi
\u2022 inme
\u2022 damar sertli\u011fi riski artabiliyor.
En \u00f6nemli nokta ise \u015fu:
LDL kolesterol\u00fcn\u00fcz normal olsa bile Lipoprotein(a) y\u00fcksekse risk devam edebilir.
Bu y\u00fczden \u201cgizli risk fakt\u00f6r\u00fc\u201d olarak da adland\u0131r\u0131l\u0131r.<\/p>\n\n\n\n
<\/strong>G\u00fcn\u00fcm\u00fczde kullan\u0131lan baz\u0131 g\u00fc\u00e7l\u00fc kolesterol ila\u00e7lar\u0131 (\u00f6rne\u011fin PCSK9 inhibit\u00f6rleri):
\u2022 LDL\u2019yi \u00e7ok ciddi d\u00fc\u015f\u00fcr\u00fcr
\u2022 Lipoprotein(a)\u2019y\u0131 ise sadece k\u0131smen azalt\u0131r
Ama bu etki yeterli de\u011fildir.
Bu nedenle bilim d\u00fcnyas\u0131 Lp(a)\u2019y\u0131 do\u011frudan hedefleyen yeni tedavilere y\u00f6nelmi\u015ftir.<\/p>\n\n\n\n
<\/strong>Son y\u0131llarda geli\u015ftirilen yeni ila\u00e7lar, Lipoprotein(a)\u2019y\u0131 do\u011frudan \u00fcretim seviyesinde azaltmay\u0131 hedefliyor.
Bu ila\u00e7lar:
\u2022 Karaci\u011ferde Lp(a) \u00fcretimini bask\u0131lar
\u2022 Enjeksiyon \u015feklinde uygulan\u0131r
\u2022 \u00c7ok g\u00fc\u00e7l\u00fc d\u00fc\u015f\u00fc\u015fler sa\u011flayabilir (baz\u0131 \u00e7al\u0131\u015fmalarda %80\u201390\u2019a kadar)
Bu tedaviler hen\u00fcz geli\u015ftirme a\u015famas\u0131nda olsa da:
Kalp hastal\u0131\u011f\u0131nda yeni bir d\u00f6nemin kap\u0131s\u0131n\u0131 aral\u0131yor.<\/p>\n\n\n\n
<\/strong>Gelecekte kalp hastal\u0131\u011f\u0131 riski de\u011ferlendirilirken sadece \u015funlara bak\u0131lmayabilir:
\u2022 Kolesterol
\u2022 Tansiyon
\u2022 \u015eeker
\u2022 Sigara
Bunlara ek olarak genetik risk fakt\u00f6rleri (\u00f6zellikle Lipoprotein(a)) daha \u00f6nemli hale gelebilir.<\/p>\n\n\n\n
<\/strong>\u00d6zellikle \u015fu ki\u015filerde \u00f6nemlidir:
\u2022 Erken ya\u015fta kalp krizi \u00f6yk\u00fcs\u00fc olanlar
\u2022 Ailesinde kalp hastal\u0131\u011f\u0131 bulunanlar
\u2022 Nedeni a\u00e7\u0131klanamayan damar t\u0131kan\u0131kl\u0131\u011f\u0131 olanlar
\u2022 Standart riskleri d\u00fc\u015f\u00fck g\u00f6r\u00fcnmesine ra\u011fmen kalp hastal\u0131\u011f\u0131 geli\u015fenler<\/p>\n\n\n\n
<\/strong>Lipoprotein(a), kalp hastal\u0131klar\u0131nda uzun y\u0131llar g\u00f6z ard\u0131 edilen bir risk fakt\u00f6r\u00fcyd\u00fc.
Bug\u00fcn ise bilim d\u00fcnyas\u0131 onu \u015f\u00f6yle tan\u0131ml\u0131yor:\u201cKolesterolden ba\u011f\u0131ms\u0131z, genetik bir kalp hastal\u0131\u011f\u0131 riski.\u201d
Geli\u015ftirilen yeni tedavilerle birlikte, gelecekte kalp hastal\u0131\u011f\u0131n\u0131 \u00f6nlemede \u00e7ok daha ki\u015fiselle\u015ftirilmi\u015f bir d\u00f6nem ba\u015flayabilir.<\/p>","protected":false},"excerpt":{"rendered":"